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Neurosurgery

David Darrow

Key Researcher

David Darrow, MD, MPH
Principal Investigator

Research Profile

Dr. David Darrow grew up in Plano, TX before heading to Texas A&M University to complete a degree in Physics and a degree in Mathematics. He attended medical and graduate school at the University of Texas Medical Branch in Galveston, TX. Following devastating hurricanes, Dr. Darrow ran a free clinic and public health programs in Texas. He completed his Master’s in Public Health and developed a passion for treating and understanding diseases of the brain and mind. He has received numerous awards and recognitions including AOA, GHHS, McGovern Award, and MLK Service award.
Dr. David Darrow is an Assistant Professor in the Department of Neurosurgery at the University of Minnesota and the Rockswold-Kaplan Endowed Chair for Traumatic Brain Injury at Hennepin County Medical Center, specializing in functional and pain neurosurgery. Dr. Darrow treats diseases of the central nervous system with neuromodulation including epilepsy, movement disorders, trigeminal neuralgia/facial pain, chronic pain, and psychiatric diseases.

Neurosurgery

Despite advances in patient care after traumatic brain and spinal cord injury, traumatic injuries to the nervous system still confer a high morbidity and mortality. The development of effective treatments and therapies to minimize complications of traumatic brain injury (TBI) and spinal cord injury (SCI) is of paramount importance. Yet, they have been hindered due to a fundamental lack of understanding of the injury processes. In order to be the leading institution for the treatment of traumatic injuries to the brain and spinal cord, a better understanding of the underlying physiology and pathology (basic science) must inform personalized and novel treatment strategies (translation) built on a foundation of ceaseless clinical improvements (quality improvement). The Neurosurgery research lab aims to investigate and bolster promising treatments/therapies through a multifaceted approach by integrating clinical and academic expertise.

Dr. Darrow is interested in functional neurosurgery and the treatment of functional diseases of the central nervous system including epilepsy, movement disorders, spinal cord injury, traumatic brain injury, and psychiatric diseases. Through his research, he works directly with biomedical engineers to unify noninvasive and invasive forms of neuromodulation with validated, model-based approaches and control theory. He specializes in clinical trials and the application of novel devices and algorithms to optimize and understand neuromodulation approaches to treating disease.

Dr. Darrow is the PI of the Traumatic Brain and Spinal Cord Research Center at HCMC where electrophysiology and neuromodulation and used to better understand and treat traumatic injuries of the central nervous system. He is the PI for the E-STAND trial, where neuromodulation is used to restore function after Spinal Cord Injury. In collaboration with many other investigators, the team is testing neuromodulation to restore volitional movement and autonomic function using algorithmic, personalized approaches through remote data collection.

Studies / Projects / Highlights

Epidural Neuromodulation for Spinal Cord Injury (E-STAND)

Cortical spreading depolarization after severe traumatic brain injury (CSD);
Depth electrode detection of cortical spreading depolarization after traumatic brain injury (Depth)

 

Affiliated Researchers

Dr. Thomas Bergman, MD Chief of Neurosurgery   https://www.hennepinhealthcare.org/provider/thomas-a-bergman-md/

Dr. Walter Galicich, MD Neurosurgeon https://www.hennepinhealthcare.org/provider/walter-e-galicich-md/

Dr. Samuel Cramer, Ph.D.

Publications

Link to PubMed: https://pubmed.ncbi.nlm.nih.gov/30667299/

Injuries from Less-Lethal Weapons during the George Floyd Protests in Minneapolis
https://pubmed.ncbi.nlm.nih.gov/33440082/

Optimization of Spinal Cord Stimulation Using Bayesian Preference Learning and Its Validation
https://pubmed.ncbi.nlm.nih.gov/34543198/

Discrepancy Between Internal and External Intracranial Pressure Transducers: Quantification of an Old Source of Error in EVDs?
https://pubmed.ncbi.nlm.nih.gov/31394360/

Advances in Epidural Spinal Cord Stimulation to Restore Function after Spinal Cord Injury: History and Systematic Review  https://www.liebertpub.com/doi/pdf/10.1089/neu.2022.0007

The safety of epidural spinal cord stimulation to restore function after spinal cord injury: post-surgical complications and incidence of cardiovascular events https://www.nature.com/articles/s41393-022-00822-w

Staff

Tara Nash, RN, FNP-BC
Research Manager

Tara became a Minnesota registered nurse in 2014. Tara had an aspiration for more education and she perused her Masters of Science in Nursing from Simmons University, Boston Massachusetts. As an advanced practice nurse in the state of Minnesota, she is able to compliment Dr. David Darrow’s research. Tara brings her nursing experience to the team to ensure there is integration between research and subject experience. Tara always states her passion for research, as a wonderful blend of science and compassion for people.

 

To make a donation to this program, click on the Donate to this Program button. In the Other box under Designation, type in Neurosurgery Fund 03275

 

 

David Darrow

Key Researcher

David Darrow, MD, MPH
Principal Investigator

Clinical Profile

Dr. David Darrow grew up in Plano, TX before heading to Texas A&M University to complete a degree in Physics and a degree in Mathematics. He attended medical and graduate school at the University of Texas Medical Branch in Galveston, TX. Following devastating hurricanes, Dr. Darrow ran a free clinic and public health programs in Texas. He completed his Master’s in Public Health and developed a passion for treating and understanding diseases of the brain and mind. He has received numerous awards and recognitions including AOA, GHHS, McGovern Award, and MLK Service award.
Dr. David Darrow is an Assistant Professor in the Department of Neurosurgery at the University of Minnesota and the Rockswold-Kaplan Endowed Chair for Traumatic Brain Injury at Hennepin County Medical Center, specializing in functional and pain neurosurgery. Dr. Darrow treats diseases of the central nervous system with neuromodulation including epilepsy, movement disorders, trigeminal neuralgia/facial pain, chronic pain, and psychiatric diseases.

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