The Berman Center supports the research mission of Hennepin Health Research Institute (HHRI) and Hennepin Health System (HHS), by serving as its primary clinical site for over 100 clinical trials and observational studies, and national coordinating center for multiple large trials. The Berman Center supports the research mission of Hennepin Health Research Institute (HHRI, founded in 1952), the third largest nonprofit medical research institution in the state of Minnesota. HHRI operates within Hennepin Healthcare, an integrated system of care that includes a nationally recognized Level I Adult and Pediatric Trauma Center, a 484-bed academic hospital, and primary care clinics. Hennepin Healthcare is the largest public hospital in Minnesota. The system is operated by Hennepin Healthcare System, a subsidiary corporation of Hennepin County.

The Berman Center provides comprehensive research services support.

Our experienced staff assists with all stages of the clinical research process, including our team of principal investigators, project managers, study coordinators, research assistants, and administrative support.

  • Refine research questions
  • Study recruitment
  • Grant writing
  • Screen, schedule and consent study participants
  • IRB and regulatory management
  • Laboratory draws, processing and shipment
  • Design study protocols
  • Multi-site study monitoring
  • Project management
  • Outpatient clinical interventions
  • Study budget development and monitoring
  • Publication support
  • Design data collection systems

We are positioned to continue our growth to serve more investigators who lead research aligned with rigorous best practices and findings that translate to improved public health; especially for studies focused on our diverse patient population. However, we cannot continue this growth without new financial resources, and have approached several potential donors to sustain the Berman Center’s tremendous success.

The Berman Center is located on the campus of Hennepin Healthcare, on the 4th floor of the Parkside Professional Center on the eastern edge of downtown Minneapolis. The Parkside Professional Center is across the street from the Hennepin Healthcare Clinic & Specialty Center, and the convenient Parkside Parking Ramp occupies its lower floors.

The office space includes administrative and medical offices, fully equipped procedure/examination rooms, laboratory phlebotomy station, a reception area for central patient coordination, a secure medical records room, recruitment stations, patient education wing, support staff facilities, and a conference room. The laboratory is equipped for drawing, processing, storing and shipping specimens for multiple study protocols. All clinical and support staff have either private or shared offices that overlook Elliot Park green space.

Current Studies


  • ASPREE (ASPirin in Reducing Events in the Elderly). Aspirin trial and ASPREE-XT observational follow on study. Dr. Anne Murray, Co-PI. U.S. coordinating center for landmark NIA study with Monash University in Melbourne, Australia in over 19,000 healthy older participants for 13 years, with over $100 million in NIH funding, and over 200 publications regarding dementia, disability, frailty, genomics, and cancer outcomes.
  • HATS (Healthy Aging in the Senior Years). Dr. Anne Murray, Co-PI, to explore reasons for the two-fold risk of dementia in older U.S. Blacks and to measure cardiovascular risk factors for dementia in 300 older Black community residents of the Twin Cities in collaboration with Mayo Clinic Co-PI Dr. David Knopman and community engagement partners Hue-MAN and the LinC.
  • Sex-Specific Risk Factors and Trajectories of Blood Biomarkers for ADRD. Anne Murray.

Addiction Medicine: Dr. Gavin Bart, PI, leads the National Institute on Drug Abuse (NIDA) Center for Clinical Trials Network (CCTN) Northstar Node for multiple studies.

  • ADAPT Accelerated Development of Additive Pharmacotherapy Treatment for Methamphetamine Use Disorder
  • EXHIT-ENTRE Exemplar Hospital Initiation Trial to Enhance Treatment Engagement
  • NORTHSTAR Clinical Trials Network
    • COMPUTE 2.0 CTN-0095: Clinic-Randomized Trial of Clinical Decision Support for Opioid Use Disorders
      in Medical Settings
    • CTN-0095-A-1: Suicide Prediction and Prevention for People at Risk for Opioid Use Disorder
    • CTN-0095-A-2: Reducing Stigma Toward People with Opioid Use Disorder Among Primary Care Clinicians
    • CTN-0096: Culturally Centered MAT for OUD Implementation Facilitation for Primary Care and Addiction Treatment Programs Serving American Indian/Alaska Natives
    • ED-INNOVATION CTN-0099: Emergency Department-INitiated bupreNOrphine and VAlidaTIOn Network
    • CURB-2 CTN-0109: Randomized, Placebo-controlled Trial of Injectable Naltrexone and Monthly Injectable Buprenorphine for Cocaine Use Disorder
    • CTN-0123: Facebook Intervention for Preventing Opioid Relapse among American Indian Women
    • CTN-0127: Engaging African American Faith-Based Leaders in a Substance Use Learning Collaborative
    • MOUD CTN-0131: Office-Based Methadone versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder —A Pragmatic Hybrid Effectiveness/Implementation Trial


  • HOPE Hemodialysis Opioid and Pain Reduction Effort. Dr. Kirsten Johansen.
  • REACH Research and Evaluation Commercialization Hubs REACH DART. Kirsten Johansen.
  • IDMS Intradialytic Myocardial Stunning

Infectious Disease

  • STRIVE Strategies and Treatments for Respiratory Infections and Viral Emergencies. Dr. Jason Baker. COVID U.S./Mexico International Coordinating Center - network support. To investigate drugs and treatment strategies for adults in the hospital with respiratory or lung infection.
  • OTAC Covid-19 outpatient observational study

Amyotrophic Lateral Sclerosis (ALS)

  • PHOENIX – Phase III Trial of AMX0035
  • CREATE/CAPTURE. DNA repository.

Historical Study Record:

Heart Disease - 10 NIH trials including:

  • ALLHAT Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack
  • SHEP Systolic Hypertension in the Elderly Program
  • Multiple industry blood pressure trials


  • FRESH (FIND) Healthy Food, Healthy Lives,
  • ACCORD Action to Control Cardiovascular Risk in Diabetes
  • ACCORDION ACCORD Follow-on Study
  • ORIGIN Outcome Reduction with Initial Glargine Intervention
  • DREAM Diabetes Related to Acute pancreatitis and its Mechanisms
  • U300 Insulin Study

Dementia/Cognitive Impairment/Health Aging

  • BRINK. BRain In Kidney Disease

Amyotrophic Lateral Sclerosis (ALS)

  • Minocycline. Antibiotic study
  • Co-Enzyme Q-10. Antioxidant study
  • IGF-I Myotrophin study
  • TCH-346 study
  • VEST study
  • SPS3 Levels of Inflammatory Markers in the Treatment of Stroke

Alternative Medicine

  • Chiropractic, Medication, and Self-Care for Neck Pain
  • Manipulation, Exercise, and Self Care for Low Back Pain/Neck Pain
  • PACBACK Housed staff and conducted participant study visits at The Berman Center


  • Fractures and bone disease in living kidney donors
  • WHI Women’s Health Initiative. Clinical site with over 5,000 participants

Moral Injury Prevention Program. Survey research and analysis

For more information about working with the Berman Center, please contact Brenda Kirpach at or 612-873-6905. You can also visit our website at