Malaria Vaccination and Immunology
Our lab has an expertise in the modulation of malaria immune responses, which started with research in Blantyre, Malawi, examining the changing epidemiology of severe malaria disease. We have demonstrated that HIV infection results in alteration in the phenotype of B cells targeting malaria associated most closely with viremia and inflammation, but serologic titers are maintained. Our lab now is focused on approaches to optimize protective immune responses in animal models.
Key Publications
Frosch AE, Odumade OA, Taylor JJ, Ireland K, Ayodo G, Ondigo B, Narum DL, Vulule J, John CC. Decrease in numbers of naïve and resting B cells in HIV infected Kenyan adults leads to a proportional increase in total and Plasmodium falciparum-specific atypical memory B cells. J Immunol. 2017;198(12):4629-4638.
Bravo M, Dileepan T, Dolan M, Hildebrand J, Wolford J, Hanson ID, Hamilton SE, Frosch AE, Burrack KS. IL-15 Complex-Induced IL-10 Enhances Plasmodium-specific CD4+ T Follicular Helper Differentiation and Antibody Production. J Immunol. 2024 Mar 15;212(6):992-1001. doi: 10.4049/jimmunol.2300525. PubMed PMID: 38305633; PubMed Central PMCID: PMC10932862.
Odhiambo EO, Datta D, Guyah B, Ayodo G, Ondigo BN, Abong'o BO, John CC, Frosch AEP. HIV infection drives IgM and IgG3 subclass bias in Plasmodium falciparum-specific and total immunoglobulin concentration in Western Kenya. Malar J. 2019 Aug 30;18(1):297. doi: 10.1186/s12936-019-2915-7. PubMed PMID: 31470903; PubMed Central PMCID: PMC6716850.
Key Collaborators
