Our lab has an expertise in the modulation of malaria immune responses, which started with research in Blantyre, Malawi, examining the changing epidemiology of severe malaria disease. We have demonstrated that HIV infection results in alteration in the phenotype of B cells targeting malaria associated most closely with viremia and inflammation, but serologic titers are maintained. This research lends insight on the impact of chronic inflammation and immunopathogy in chronic/recurrent immune responses. We are now conducting studies to understand how this type of inflammation may affect vaccine immunity.