Center for Infectious Disease Research (CeIDeR) Team

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CeIDer Team

Principal Investigators

Professor of Medicine, University of Minnesota Medical School

I have been a physician-scientist at Hennepin Healthcare since 2007 and Director of the Infectious Diseases Division since 2018. I provide infectious diseases consultation and HIV primary care. I was drawn to Hennepin Healthcare for the clinical and research mission, and the opportunity to work alongside talented colleagues. My research program includes pathogenesis-oriented studies and clinical trials that inform the management of infectious diseases. My HIV research portfolio primarily involves the management of long-term complications of HIV disease, such as cardiovascular disease and risk for heart failure, conducted both locally as well as in South Africa. My COVID research portfolio includes clinical trials of novel treatments as well as a focus on cardiac complications. Finally, I direct an international clinical coordinating center within the NIH/NIAID-funded STRIVE (Strategies and Treatments for Respiratory Infections and Viral Emergencies) network, where I also serve as protocol chair for an ongoing trial.

Education and training

Infectious Diseases Clinical and Research Fellowship, University of Minnesota Medical School, Minneapolis, MN
Masters of Clinical Research, University of Minnesota Medical School, Minneapolis, MN
Internal Medicine Internship and Residency, Oregon Health and Science University, Portland, OR
MD, University of Wisconsin-Madison, Madison, WI
BS, University of Wisconsin-Madison, Madison, WI

Recent Publications

NIH My Bibliography

Grants

Other Key Professional Activities

Member, U.S. DHHS Panel on Guidelines for the Use of Antiretroviral Agents for Adults and Adolescents Living with HIV.
Member, U.S. NIH Panel on Coronavirus Disease 2019 (COVID-10) Treatment Guidelines.

Kristina Burrack, PhD

Assistant Professor of Medicine, University of Minnesota Medical School

My long-term research goal is to develop a comprehensive understanding of host-pathogen interactions to enhance immunity and limit immune-mediated pathology with an emphasis on investigating infections and improving vaccination strategies against deadly diseases such as malaria and other pathogens of global health importance. Additionally, the knowledge gained from these studies will be applied to improving adoptive cell therapies to treat cancer and limit immune-mediated damage.

Education and training

Postdoctoral Fellowship, University of Minnesota Medical School, Minneapolis, MN
PhD, University of Colorado Anschutz Medical Campus, Aurora, CO
BA, St. Olaf College, Northfield, MN

Recent Publications

NCBI My Bibliography

Grants

R01 HD108015-01 (NICHD): Mechanisms of innate immune dysfunction in SIV/malaria co-infection in pregnancy role; 01/2022 – 12/2026; Consultant
R01 RHL158756A (NHLBI), role: Immunologic basis of cardiac disease after severe COVID-19; 04/2022 – 03/2026; Co-Investigator
K22 AI143969-01A1 (NIAID): Investigating IL-10-producing suppressive NK cells; 06/2020 – 09/2022; PI
UL1TR002494 (NCATS): Investigating IL-10-producing natural killer cells and their immune-modulatory functions; 03/2022 – 02/2024; K-R01 Scholar

Anne Frosch, MD, MPH

Anne Frosch, MD MPH

Assistant Professor of Medicine, University of Minnesota Medical School

Vaccine Committee Co-chair, Hennepin Healthcare

I am a physician-scientist who runs a laboratory that examines adaptive immune responses to vaccines and infection. Our laboratory does this through the recruitment and maintenance of clinical cohorts and advanced immunologic assays that allow us to study specialized immune system cells specific to a pathogen or vaccine. We have applied these tools in the study of malaria, HIV, COVID-19, and vaccination. Our long-term goal is to understand how unique characteristic of a patient or pathogen shape the immune response and future protection to guide the design of more effective and safe vaccines.

Education and training

Infectious Disease Fellowship, University of Minnesota Medical School, Minneapolis, MN
Postdoctoral Fellowship, Center for Vaccine Development, University of Maryland, Baltimore, MD
MPH, Johns Hopkins University, Baltimore, MD
MD, Mayo Medical School, Rochester, MN
BA, Art History and Biological Sciences, Northwestern University, Evanston, IL

Recent Publications

NCBI My Bibliography

Grants

K08-AI141761-01A1 (NIH): Memory T follicular helper cell kinetics and localization during recall immune responses to tetanus vaccination; 2019-2024; Principal Investigator
R01 (NHLBI): Immunologic basis of cardiac disease after severe COVID-19; 2022-2027; Co-investigator
(CDC): Influenza and Other Viruses in the Acutely Ill (IVY) Network; 2022-present; Co-investigator
University of Minnesota Masonic Cross Departmental Grant for Children’s Health: Optimizing iron status while minimizing morbidity in HIV-infected Ugandan children; 2016-2018; Co-Principal Investigator
F32 (NIAID). AI109808-01: The effects of HIV on malaria specific T and B cell responses; 2014-2015; Principal Investigator
(American Society of Tropical Medicine and Hygiene): Centennial Award

Teaching Activities

My teaching focus is in providing one on one mentorship for physicians and scientists interested in translational research. Numerous mentees have gone on to obtain PhD’s and faculty positions in biomedical science in the United States and abroad. All of these students and collaborators have significantly shaped our work through their intellect, passion and commitment to research that improves human health.

Morgan Harris, Scripps Research
Gayathri Dileepan, Ohio State University
Eliud Odhiambo, Indiana University
Oludare Odumade, Harvard Medical School
Bartholomew Ondigo, Egerton University
Kristina Burrack, Hennepin Healthcare Research Institute, University of Minnesota

Other Key Professional Activities

With my research and clinical experience in the care of patients with malaria, I have advocated within Hennepin Healthcare Research Institute, Minnesota, and nationally for the availability of medications for the treatment of severe malaria in travelers. This has included partnering with members of Congress, community members who work with high-risk travelers, and the Minnesota Department of Health to increase access to safe and affordable malaria treatment and prevention.

Frosch AEP, Ahiskali A, John CC. Unaffordable treatment for severe malaria highlights U.S. drug market pitfalls. STAT. June 11, 2021

Frosch AEP. Artesunate versus quinine: Keeping our options open. Clin Infect Dis. 2020; 70(2):288-289.

Frosch AE, Thielen BK, Alpern JD, et al. Antimalarial chemoprophylaxis and treatment in the USA: Limited access and extreme price variability. J Travel Med. 2022;29(4);taab117.

Minnesota Department of Health Malaria Community Advisory Board

Working with CDC and Congress to provide easy access to severe malaria treatment for Minnesotans

Amanda Noska, MD, MPH

Assistant Professor of Medicine, University of Minnesota Medical School

Medical Director, Positive Care Clinic, Hennepin Healthcare

I was drawn to Hennepin Healthcare because of the organization’s mission to care for marginalized populations and because of the outstanding caliber of colleagues within this organization. My research interests include clinical pharmaceutical trials for HIV and viral hepatitis B and C. In the past, I’ve also examined factors that influence the quality of care for persons living with HIV, HCV, and/or HBV, those with substance use disorders, homelessness, and/or a history of incarceration. I have been Medical Director of Positive Care at Hennepin Healthcare since January 2022.

Education and training

Infectious Disease Fellowship, Brown University, Lifespan Hospitals, Providence, RI
Internal Medicine Internship and Residency, Hennepin County Medical Center, Minneapolis, MN
MD, University of Minnesota Medical School, Minneapolis, MN
MPH, University of Minnesota School of Public Health, Minneapolis, MN
BA, The College of St. Scholastica, Duluth, MN

Recent Publications

PubMed

Note: The link above brings you to a PubMed search by author name and, as such, may incorrectly contain publications authored by others with a similar name.

Grants

GSK-219288 (GlaxoSmithKline); Study of Bepirovirsen in Nucleos(t)Ide Analogue-treated Participants With Chronic Hepatitis B (B-Well 2) (B-Well 2); 2023-Present; Principal Investigator

Jenell Stewart, DO, MPH

Assistant Professor of Medicine, University of Minnesota Medical School

I am a board-certified physician providing infectious diseases and HIV specialty care at Hennepin Healthcare (starting in 2022) following clinical training and launching my research career at the University of Washington. I am researching the prevention of STIs and HIV among women. Over the past decade, I worked in clinics and conducted collaborative research on HIV and sexually transmitted diseases among cisgender women exchanging sex in Callao, Peru; Mombasa, Kenya; Naivasha, Kenya; and Seattle, USA. My current clinical and behavioral research is at the intersection of HIV/STIs, adherence, and gender in two primary areas of research: first, clinical trials of doxycycline post-exposure prophylaxis (dPEP) for prevention of bacterial STIs among cisgender women taking HIV PrEP, and second, community-based care models for women who exchange sex and inject drugs.

Education and training

Infectious Diseases Fellowship, University of Washington, Seattle, WA
Global Health Chief Resident, University of Washington, Seattle, WA
Internal Medicine Internship and Residency, University of Washington, Seattle, WA
DO, Des Moines University, Des Moines, IA
MPH, Des Moines University, Des Moines, IA
BA, St. Olaf College, Northfield, MN

Recent Publications

NCBI My Bibliography

Grants

R01 AI145971 Supp (NIAID): Doxycycline post-exposure prophylaxis for prevention of sexually transmitted infections among Kenyan women using HIV pre-exposure prophylaxis (PrEP and dPEP); 09/01/19—07/31/24; Project Director, Co-Investigator
K23 MH124466 (NIMH): Understanding STI and HIV prevention adherence among Kenyan women;07/01/20-06/30/25; Principal Investigator
R34 DA054588-01A1 (NIAID): Combination primary care and prevention services for women who inject drugs and exchange sex in Seattle, Washington;08/25/22-08/24/25; Multiple Principal Investigator (contact PI)
INV-017062 (Bill & Melinda Gates Foundation): Efficacy of Novel Agents for Treatment of SARS-CoV-2 Infection Among High-Risk Outpatient Adults: An Adaptive Randomized Platform Trial; 04/15/20-04/14/21; Site Principal Investigator
INV-016204 (Bill and Melinda Gates Foundation): Efficacy of post‐exposure prophylaxis (PEP) to prevent severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection: A open‐label, randomized study of hydroxychloroquine among adults exposed to coronavirus disease (COVID‐19); 03/24/20-09/30/21; Co-Investigator
T32 AI007044 (NIAID): Host defense training in allergy and infectious diseases.07/01/18-06/31/20; Trainee, Infectious Diseases Fellow.
R24 TW007988: Fogarty International Clinical Research Scholars Support Center.07/01/11-06/31/12; Scholar

Diana Zychowski, MD, MPH

Assistant Professor of Medicine, University of Minnesota Medical School

My research centers on the clinical epidemiology, laboratory diagnostics, and host immune response to tick-borne infections, with a particular focus on emerging tick-borne viruses and tick-associated conditions such as Alpha-gal syndrome. Through the development of novel molecular diagnostic tools and a One Health framework, I work to bridge academic medicine and public health surveillance to better detect, understand, and ultimately treat these underrecognized diseases. As a first-generation college graduate, mentorship has been instrumental in my own training, and I am deeply committed to fostering an inclusive research environment that supports trainees from all backgrounds in developing the skills and confidence to pursue careers in science and medicine.

Education and training

Postdoctoral Fellowship, University of North Carolina at Chapel Hill; Chapel Hill, NC
Infectious Disease Fellowship, University of North Carolina at Chapel Hill; Chapel Hill, NC
Internal Medicine, Global Health Pathway Resident, University of Minnesota; Minneapolis, MN
MD, Virginia Tech Carilion School of Medicine and Research Institute; Roanoke, VA
Certificate for Research in Translational Medicine, Virginia Polytechnic Institute and State University; Blacksburg, VA
MPH, Epidemiology and Biostatistics, University of Illinois; Chicago, IL
BS, Applied Mathematics, Molecular/Cell Biology, University of Illinois, Urbana-Champaign; Champaign, IL