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Transforming health and healthcare for all through ethical research and meaningful community partnerships.

Research Areas

At the Hennepin Healthcare Research Institute (HHRI), we've been investigating the causes of and potential treatments for diseases since 1952. We support and oversee medical research at HCMC, Hennepin Healthcare's acute care and teaching hospital.  Our research topics are diverse with a focus on four areas: Acute Care/Trauma, Addiction, Health Services and Infectious Diseases (HIV/AIDS). Innovative discoveries made at HHRI improve the lives of patients in our local community and across the globe.

HHRI Research Highlights

Building a Healthier Minnesota, One Data Point at a Time

September 29, 2026

What started as a COVID-19 project has grown into something bigger than anyone imagined. When the COVID-19 pandemic struck in 2020, healthcare systems were operating with limited data to understand how Minnesotans were being impacted and make informed decisions about where to deploy resources. Enter the Minnesota Electronic Health Records Consortium (MN EHRC). The MN…

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The Scientific Registry of Transplant Recipients Contract Operations to Be Assumed in Part by Publicis Sapient, Succeeding Hennepin Healthcare Research Institute

September 22, 2026

A transition is underway in the management of the nation’s transplant data infrastructure. Publicis Sapient, a global digital business transformation company, is in the process of taking over fundamental elements of the Scientific Registry of Transplant Recipients (SRTR) contract, from the Hennepin Healthcare Research Institute (HHRI). The transition is currently in progress. The IT infrastructure…

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Celebrating 60 Years of the IRB Protecting Research Participants

August 31, 2026

For 60 years, the Hennepin Healthcare Institutional Review Board (IRB) has helped ensure research is conducted safely, ethically and with the rights and well-being of participants at the forefront. Since its beginnings in 1966 as the Research Advisory Committee, the IRB has provided independent oversight for studies that involve people, evolving alongside Hennepin Healthcare’s research…

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